diff --git a/CHANGELOG.md b/CHANGELOG.md
index e0cf79c9..baecec7b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,3 +1,6 @@
+## 0.0.49 (2023-05-19)
+- **core**: 解决当组件被销毁，业务若异步（定时器）调用setState修改状态，可能出现路径错误问题。
+
 ## 0.0.48 (2023-05-18)
 - **core**: 解决style中属性WebkitLineClamp值被转换成字符串问题
 
diff --git a/libs/horizon/package.json b/libs/horizon/package.json
index 71fad88d..35b506ef 100644
--- a/libs/horizon/package.json
+++ b/libs/horizon/package.json
@@ -4,7 +4,7 @@
   "keywords": [
     "horizon"
   ],
-  "version": "0.0.48",
+  "version": "0.0.49",
   "homepage": "",
   "bugs": "",
   "main": "index.js",
diff --git a/libs/horizon/src/dom/DOMOperator.ts b/libs/horizon/src/dom/DOMOperator.ts
index a7abe22d..f83893e5 100644
--- a/libs/horizon/src/dom/DOMOperator.ts
+++ b/libs/horizon/src/dom/DOMOperator.ts
@@ -141,7 +141,7 @@ export function newTextDom(text: string, processing: VNode): Text {
   return textNode;
 }
 
-// 提交vNode的类型为Component或者Text的更新
+// 提交vNode的类型为DomComponent或者DomText的更新
 export function submitDomUpdate(tag: string, vNode: VNode) {
   const newProps = vNode.props;
   const element: Element | null = vNode.realNode;
diff --git a/libs/horizon/src/dom/validators/ValidateProps.ts b/libs/horizon/src/dom/validators/ValidateProps.ts
index d6629b29..f025ce63 100644
--- a/libs/horizon/src/dom/validators/ValidateProps.ts
+++ b/libs/horizon/src/dom/validators/ValidateProps.ts
@@ -98,7 +98,7 @@ export function validateProps(type, props) {
     return;
   }
 
-  // 非内置的变迁
+  // 非内置的元素
   if (!isNativeElement(type, props)) {
     return;
   }
diff --git a/libs/horizon/src/renderer/TreeBuilder.ts b/libs/horizon/src/renderer/TreeBuilder.ts
index eb20b0ef..9798bb8a 100644
--- a/libs/horizon/src/renderer/TreeBuilder.ts
+++ b/libs/horizon/src/renderer/TreeBuilder.ts
@@ -179,6 +179,11 @@ function isEqualByIndex(idx: number, pathArrays: string[][]) {
 function getChildByIndex(vNode: VNode, idx: number) {
   let node = vNode.child;
   for (let i = 0; i < idx; i++) {
+    // 场景：当组件被销毁，业务若异步（定时器）调用setState修改状态，可能出现路径错误，此处进行保护。
+    if (node == null) {
+      return null;
+    }
+
     node = node.next;
   }
   return node;
diff --git a/libs/horizon/src/renderer/components/BaseClassComponent.ts b/libs/horizon/src/renderer/components/BaseClassComponent.ts
index de4ff351..70b09ee4 100644
--- a/libs/horizon/src/renderer/components/BaseClassComponent.ts
+++ b/libs/horizon/src/renderer/components/BaseClassComponent.ts
@@ -33,7 +33,7 @@ class Component<P, S, C> {
 
   setState(state: S, callback?: Callback) {
     if (isDev) {
-      console.error('Cant not call `this.setState` in the constructor of class component, it will do nothing');
+      console.error('Can not call `this.setState` in the constructor of class component, it will do nothing');
     }
   }
 }