diff --git a/changelog/2922.trivial b/changelog/2922.trivial
new file mode 100644
index 000000000..06d1346bb
--- /dev/null
+++ b/changelog/2922.trivial
@@ -0,0 +1 @@
+Configure ``pytest`` to prevent pip from installing pytest in unsupported Python versions.
diff --git a/setup.py b/setup.py
index c4fc48920..54ec9581a 100644
--- a/setup.py
+++ b/setup.py
@@ -83,6 +83,7 @@ def main():
         cmdclass={'test': PyTest},
         # the following should be enabled for release
         setup_requires=['setuptools-scm'],
+        python_requires='>=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*',
         install_requires=install_requires,
         extras_require=extras_require,
         packages=['_pytest', '_pytest.assertion', '_pytest._code'],