diff --git a/setup.py b/setup.py
index 2f49078fa..4c87c6429 100644
--- a/setup.py
+++ b/setup.py
@@ -4,7 +4,6 @@ from setuptools import setup
 #       remove _width_of_current_line in terminal.py
 INSTALL_REQUIRES = [
     "py>=1.5.0",
-    "six>=1.10.0",
     "packaging",
     "attrs>=17.4.0",
     "more-itertools>=4.0.0",
diff --git a/src/_pytest/assertion/rewrite.py b/src/_pytest/assertion/rewrite.py
index 4226a97b3..9b431b984 100644
--- a/src/_pytest/assertion/rewrite.py
+++ b/src/_pytest/assertion/rewrite.py
@@ -14,7 +14,6 @@ from importlib.util import spec_from_file_location
 
 import atomicwrites
 import py
-import six
 
 from _pytest._io.saferepr import saferepr
 from _pytest.assertion import util
@@ -612,7 +611,7 @@ class AssertionRewriter(ast.NodeVisitor):
         # Insert some special imports at the top of the module but after any
         # docstrings and __future__ imports.
         aliases = [
-            ast.alias(six.moves.builtins.__name__, "@py_builtins"),
+            ast.alias("builtins", "@py_builtins"),
             ast.alias("_pytest.assertion.rewrite", "@pytest_ar"),
         ]
         doc = getattr(mod, "docstring", None)
diff --git a/src/_pytest/fixtures.py b/src/_pytest/fixtures.py
index 365f0ae6b..2f9b10b85 100644
--- a/src/_pytest/fixtures.py
+++ b/src/_pytest/fixtures.py
@@ -9,7 +9,6 @@ from collections import OrderedDict
 
 import attr
 import py
-import six
 
 import _pytest
 from _pytest import nodes
@@ -848,10 +847,10 @@ class FixtureDef:
                 except:  # noqa
                     exceptions.append(sys.exc_info())
             if exceptions:
-                e = exceptions[0]
+                _, val, tb = exceptions[0]
                 # Ensure to not keep frame references through traceback.
                 del exceptions
-                six.reraise(*e)
+                raise val.with_traceback(tb)
         finally:
             hook = self._fixturemanager.session.gethookproxy(request.node.fspath)
             hook.pytest_fixture_post_finalizer(fixturedef=self, request=request)
@@ -877,7 +876,8 @@ class FixtureDef:
             result, cache_key, err = cached_result
             if my_cache_key == cache_key:
                 if err is not None:
-                    six.reraise(*err)
+                    _, val, tb = err
+                    raise val.with_traceback(tb)
                 else:
                     return result
             # we have a previous but differently parametrized fixture instance
@@ -950,7 +950,7 @@ def wrap_function_to_error_out_if_called_directly(function, fixture_marker):
         name=fixture_marker.name or function.__name__
     )
 
-    @six.wraps(function)
+    @functools.wraps(function)
     def result(*args, **kwargs):
         fail(message, pytrace=False)
 
diff --git a/src/_pytest/logging.py b/src/_pytest/logging.py
index f3034d8e5..ac0c4c2b3 100644
--- a/src/_pytest/logging.py
+++ b/src/_pytest/logging.py
@@ -4,7 +4,6 @@ import re
 from contextlib import contextmanager
 
 import py
-import six
 
 import pytest
 from _pytest.compat import dummy_context_manager
@@ -66,34 +65,31 @@ class ColoredLevelFormatter(logging.Formatter):
         return super().format(record)
 
 
-if not six.PY2:
-    # Formatter classes don't support format styles in PY2
+class PercentStyleMultiline(logging.PercentStyle):
+    """A logging style with special support for multiline messages.
 
-    class PercentStyleMultiline(logging.PercentStyle):
-        """A logging style with special support for multiline messages.
+    If the message of a record consists of multiple lines, this style
+    formats the message as if each line were logged separately.
+    """
 
-        If the message of a record consists of multiple lines, this style
-        formats the message as if each line were logged separately.
-        """
+    @staticmethod
+    def _update_message(record_dict, message):
+        tmp = record_dict.copy()
+        tmp["message"] = message
+        return tmp
 
-        @staticmethod
-        def _update_message(record_dict, message):
-            tmp = record_dict.copy()
-            tmp["message"] = message
-            return tmp
-
-        def format(self, record):
-            if "\n" in record.message:
-                lines = record.message.splitlines()
-                formatted = self._fmt % self._update_message(record.__dict__, lines[0])
-                # TODO optimize this by introducing an option that tells the
-                # logging framework that the indentation doesn't
-                # change. This allows to compute the indentation only once.
-                indentation = _remove_ansi_escape_sequences(formatted).find(lines[0])
-                lines[0] = formatted
-                return ("\n" + " " * indentation).join(lines)
-            else:
-                return self._fmt % record.__dict__
+    def format(self, record):
+        if "\n" in record.message:
+            lines = record.message.splitlines()
+            formatted = self._fmt % self._update_message(record.__dict__, lines[0])
+            # TODO optimize this by introducing an option that tells the
+            # logging framework that the indentation doesn't
+            # change. This allows to compute the indentation only once.
+            indentation = _remove_ansi_escape_sequences(formatted).find(lines[0])
+            lines[0] = formatted
+            return ("\n" + " " * indentation).join(lines)
+        else:
+            return self._fmt % record.__dict__
 
 
 def get_option_ini(config, *names):
@@ -464,8 +460,7 @@ class LoggingPlugin:
         else:
             formatter = logging.Formatter(log_format, log_date_format)
 
-        if not six.PY2:
-            formatter._style = PercentStyleMultiline(formatter._style._fmt)
+        formatter._style = PercentStyleMultiline(formatter._style._fmt)
         return formatter
 
     def _setup_cli_logging(self):
diff --git a/src/_pytest/runner.py b/src/_pytest/runner.py
index 2561aaf46..9c91a49a5 100644
--- a/src/_pytest/runner.py
+++ b/src/_pytest/runner.py
@@ -5,7 +5,6 @@ import sys
 from time import time
 
 import attr
-import six
 
 from .reports import CollectErrorRepr
 from .reports import CollectReport
@@ -304,7 +303,8 @@ class SetupState:
                 if exc is None:
                     exc = sys.exc_info()
         if exc:
-            six.reraise(*exc)
+            _, val, tb = exc
+            raise val.with_traceback(tb)
 
     def _teardown_with_finalization(self, colitem):
         self._callfinalizers(colitem)
@@ -339,7 +339,8 @@ class SetupState:
                 if exc is None:
                     exc = sys.exc_info()
         if exc:
-            six.reraise(*exc)
+            _, val, tb = exc
+            raise val.with_traceback(tb)
 
     def prepare(self, colitem):
         """ setup objects along the collector chain to the test-method
@@ -350,7 +351,8 @@ class SetupState:
         # check if the last collection node has raised an error
         for col in self.stack:
             if hasattr(col, "_prepare_exc"):
-                six.reraise(*col._prepare_exc)
+                _, val, tb = col._prepare_exc
+                raise val.with_traceback(tb)
         for col in needed_collectors[len(self.stack) :]:
             self.stack.append(col)
             try:
diff --git a/testing/code/test_source.py b/testing/code/test_source.py
index 2462d773e..72bc628ab 100644
--- a/testing/code/test_source.py
+++ b/testing/code/test_source.py
@@ -5,8 +5,6 @@ import ast
 import inspect
 import sys
 
-import six
-
 import _pytest._code
 import pytest
 from _pytest._code import Source
diff --git a/testing/logging/test_formatter.py b/testing/logging/test_formatter.py
index 8adc26613..806f4563a 100644
--- a/testing/logging/test_formatter.py
+++ b/testing/logging/test_formatter.py
@@ -1,9 +1,7 @@
 import logging
 
 import py.io
-import six
 
-import pytest
 from _pytest.logging import ColoredLevelFormatter
 
 
@@ -38,9 +36,6 @@ def test_coloredlogformatter():
     assert output == ("dummypath                   10 INFO     Test Message")
 
 
-@pytest.mark.skipif(
-    six.PY2, reason="Formatter classes don't support format styles in PY2"
-)
 def test_multiline_message():
     from _pytest.logging import PercentStyleMultiline
 
diff --git a/testing/logging/test_reporting.py b/testing/logging/test_reporting.py
index 690a0c5b8..68be819b9 100644
--- a/testing/logging/test_reporting.py
+++ b/testing/logging/test_reporting.py
@@ -1,8 +1,7 @@
+import io
 import os
 import re
 
-import six
-
 import pytest
 
 
@@ -885,7 +884,7 @@ def test_live_logging_suspends_capture(has_capture_manager, request):
             yield
             self.calls.append("exit disabled")
 
-    class DummyTerminal(six.StringIO):
+    class DummyTerminal(io.StringIO):
         def section(self, *args, **kwargs):
             pass
 
diff --git a/testing/python/fixtures.py b/testing/python/fixtures.py
index 2dc3b4308..a9ea333ad 100644
--- a/testing/python/fixtures.py
+++ b/testing/python/fixtures.py
@@ -1357,9 +1357,8 @@ class TestFixtureManagerParseFactories:
 
     def test_parsefactories_conftest_and_module_and_class(self, testdir):
         testdir.makepyfile(
-            """
+            """\
             import pytest
-            import six
 
             @pytest.fixture
             def hello(request):
@@ -1376,7 +1375,7 @@ class TestFixtureManagerParseFactories:
                     assert faclist[0].func(item._request) == "conftest"
                     assert faclist[1].func(item._request) == "module"
                     assert faclist[2].func(item._request) == "class"
-        """
+            """
         )
         reprec = testdir.inline_run("-s")
         reprec.assertoutcome(passed=1)
diff --git a/testing/python/metafunc.py b/testing/python/metafunc.py
index 305346782..4702f0b57 100644
--- a/testing/python/metafunc.py
+++ b/testing/python/metafunc.py
@@ -892,7 +892,7 @@ class TestMetafuncFunctional:
         p = testdir.makepyfile(
             """
             # assumes that generate/provide runs in the same process
-            import sys, pytest, six
+            import sys, pytest
             def pytest_generate_tests(metafunc):
                 metafunc.parametrize('metafunc', [metafunc])
 
@@ -910,7 +910,7 @@ class TestMetafuncFunctional:
                 def test_method(self, metafunc, pytestconfig):
                     assert metafunc.config == pytestconfig
                     assert metafunc.module.__name__ == __name__
-                    unbound = six.get_unbound_function(TestClass.test_method)
+                    unbound = TestClass.test_method
                     assert metafunc.function == unbound
                     assert metafunc.cls == TestClass
         """
diff --git a/testing/test_unittest.py b/testing/test_unittest.py
index 410dabfce..a8555b353 100644
--- a/testing/test_unittest.py
+++ b/testing/test_unittest.py
@@ -917,7 +917,7 @@ def test_class_method_containing_test_issue1558(testdir):
 
 
 @pytest.mark.parametrize(
-    "base", ["six.moves.builtins.object", "unittest.TestCase", "unittest2.TestCase"]
+    "base", ["builtins.object", "unittest.TestCase", "unittest2.TestCase"]
 )
 def test_usefixtures_marker_on_unittest(base, testdir):
     """#3498"""